The International ANE Medical & Scientific Network
The following clinicians and researchers collaborate internationally to improve the understanding, diagnosis and treatment of Acute Necrotizing Encephalopathy (ANE), including RANBP2-associated ANE.
About this network
These experts form part of a growing international group focused on improving the understanding, diagnosis and treatment of Acute Necrotizing Encephalopathy (ANE). Together, they combine expertise in paediatric neurology, immunology, intensive care, virology, genetics and molecular biology to advance research and improve outcomes for children and adults affected by ANE worldwide.
Clinicians
Physicians who diagnose and treat children with ANE, and help analyse treatment outcomes.
Dr. Dewi Bakker
Paediatric Neurologist
Amsterdam UMC · Netherlands
Emergency protocol contributorOne of the few clinicians worldwide focused on ANE, with a long-standing interest in inflammatory disorders of the brain. He helped identify a regional genetic cluster of the disease.
Prof. Ming Lim, MD, PhD
Consultant Paediatric Neurologist
Evelina London Children's Hospital, Guy's & St Thomas' NHS Foundation Trust · United Kingdom
Emergency protocol contributorInternational expert in neuroinflammation with extensive experience in the clinical management and research of ANE and other infection-triggered encephalopathy syndromes.
Prof. Taco Kuijpers, MD, PhD
Professor of Paediatric Immunology; Consultant, Infectious Disease & Clinical Immunology
Emma Children's Hospital, Amsterdam UMC · Netherlands
Emergency protocol contributorInternational authority on paediatric immunology and immune dysregulation, and a Dutch clinical expert involved in ANE research and patient care.
Prof. E. Ann Yeh, MA, MD, FRCPC, Dip ABPN
Professor, Faculty of Medicine, University of Toronto
The Hospital for Sick Children (SickKids) · Canada
Emergency protocol contributorOne of the world's leading clinician-scientists in paediatric neuroinflammatory diseases, including ANE. She directs the Pediatric MS and Neuroinflammatory Disorders Program and holds the Garry Hurvitz Chair in Neurology at SickKids, where she is also a Senior Scientist, combining clinical care with international research.
Dr. Mia Westerholm-Ormio, MD, PhD
Consultant Paediatric Neurologist
Helsinki University Hospital · Finland
Emergency protocol contributorPaediatric neurologist at Helsinki University Hospital, with expertise in paediatric neuroinflammatory diseases and neuro-oncology.
Prof. Kumaran Deiva, MD, PhD
Professor of Paediatric Neurology
Bicêtre & Trousseau Hospitals (AP-HP), Paris-Saclay University · France
Coordinator of the French National Reference Centre for Rare Neuroimmune Disorders (MIRCEM) and Neuroimmune Lead for the European Reference Network ERN-RITA. International expert in paediatric neuroimmune disorders, leading clinical and translational research in ANE and other rare neuroimmune diseases.
Dr. Wiem Barbaria
Paediatrician & Associate Professor
Habib Bougatfa University Hospital, Bizerte · Tunisia
Paediatrician and associate professor at the Faculty of Medicine of Tunis, specialising in paediatric care and neonatology, and dedicated to advancing emergency protocols and clinical management for acute paediatric disorders.
Dr. Federica Barzaghi, MD, PhD
Paediatrician, Immunohaematology Unit
IRCCS San Raffaele Hospital, Milan · Italy
Emergency protocol contributorPhysician-scientist focusing on the diagnosis, management and development of advanced therapies for inborn errors of immunity, particularly immune dysregulation disorders. Involved in the care of patients with ANE and contributing to international guidelines from the immunological perspective.
Dr. Ineke Lunsing
Paediatric Neurologist
University Medical Center Groningen (UMCG) · Netherlands
Emergency protocol contributorPaediatric neurologist at UMCG, with expertise in neurometabolic disorders, neonatal neurology and developmental disorders. She is part of the hospital's expertise centre for rare genetic disorders and its neurometabolic treatment team.
Researchers & Scientists
Scientists investigating the mechanisms, genetics and treatment of ANE.
Dr. Nathalie J. Arhel, PhD
CNRS Research Director
Centre national de la recherche scientifique (CNRS) · France
Emergency protocol contributorResearch Director in immunovirology, focusing on RANBP2 biology, nuclear pore function, influenza virus infection, and the inflammatory mechanisms underlying ANE.
Dr. Theo Moraes, MD, PhD
Clinician-Scientist, Respiratory Medicine
The Hospital for Sick Children (SickKids), University of Toronto · Canada
Clinician-scientist and respirologist at SickKids and Senior Scientist in Translational Medicine, University of Toronto. His laboratory studies respiratory viruses and the regulation of mRNA translation by the nucleoporin RANBP2/Nup358 — biology central to ANE.
Dr. Alex Palazzo
Professor, Department of Biochemistry
Temerty Faculty of Medicine, University of Toronto · Canada
Emergency protocol contributorMolecular biologist investigating the role of RanBP2 in regulating gene expression and cytokine production in response to viral infection and the innate immune response.
Hsiuyi Chen
Senior Scientist
A*STAR Infectious Diseases Labs · Singapore
Geneticist investigating the genetic mutations and structures that cause ANE.
Are you a clinician or researcher working on ANE?
We're building an international network of specialists to strengthen care, research and awareness for families affected by ANE. If you diagnose, treat or study the condition, we'd love to hear from you.
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