With a small widespread patient base, research into ANE has been challenging for the medical profession. Dr Derek Neilson studies genetic contributions to the disorder in the United States in particular with RANBP2. In Japan, Professor Masashi Mizuguchi and his team continue their research into ANE, having completed a study on its links with HLA Genotypes in Japanese children. Research into the Auto Immune response, particularly associations with Anti-Eph antibody is another area that is yet to be fully investigated. Other fields of research may impact on the triggers of ANE such as vaccinations for the Herpes Simplex virus. Slowly case reports are being published internationally and these to will assist researchers in the future. Below are just a few articles that show whilst limited by patient numbers and funding, research is ongoing in many countries.
*Acute Necrotizing Encephalopathy Type 1 – Genetics Home Reference
Reviewed: July 2016 Published: March 2017
*RAN BP 2 – Genetics Home Reference
Familial acute necrotizing encephalopathy with RANBP2 mutation: The first report in Northeast Asia
January 31, 2017
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review
Aug. 7, 2017
*Specific HLA genotypes confer susceptibility to Acute Necrotizing Encephalopathy – Genes & Immunity Journal Advance online publication July2016
Electroencephalography and Brain Imaging Patterns in Children with Acute Encephalopathy
Arhan et al., J Neurol Neurophysiol 2016, 7:3
*Acute Necrotizing Encephalopathy: An Under recognized Clinical radiologic Disorder
Mediators of Inflammation Volume 2015
*Acute Necrotizing Encephalopathy: Neuroimaging Diagnosis and Differentials
April 25-30 2015
RANBP2 mutation tied to HHV-6 acute encephalopathy
*A severity score for acute necrotizing encephalopathy
A severe neurological complication of influenza in a previously well child
*Influenza Encephalopathy 7 Related Neuro psychiatric Syndromes – Wiley Online Library – First Published 12 November 2013
*Post infectious family case of Acute Necrotizing Encephalopathy caused by RANBP2 gene mutation.
*Acute Necrotizing Encephalopathy of Childhood; A Case Report
*Acute Necrotising Encephalitis In Young Adult Female: A Rare Experience
MRI gadolinium enhancement precedes neuroradiological findings in acute necrotizing encephalopathy.
*Immunomodulatory therapy in recurrent acute necrotizing encephalopathy ANE1: Is it useful?
May 2012 Volume 34, Issue 5, Pages 384–391
*Influenza Can Cause Brain Damage
September 22, 2011
*Neuropathologic Correlates for DTI in post-infectious encephalopathy Short running title: DTI in ANE and ADEM.
*Recurrent Acute Necrotizing Encephalopathy in a Canadian Aboriginal Child
*Novel Human Reovirus Isolated from Children with Acute Necrotizing Encephalopathy
*Genetic basis for acute necrotizing encephalopathy of childhood
*Clinical Brief: Acute Necrotizing Encephalopathy
*Acute Necrotizing Encephalopathy Progressing to Brain Death in a Pediatric Patient with Novel Influenza A (H1N1) Infection
Acute necrotizing encephalopathy of childhood with spinal cord involvement: a case report.
*EMERGENCE OF ACUTE NECROTISING ENCEPHALOPATHY IN AUSTRALIA
3 February 2008
*Acute Necrotizing Encephalopathy of Childhood: Correlation of MR Findings and Clinical Outcome
Acute Necrotizing Encephalopathy in Korean Infants and Children: Imaging Findings and Diverse Clinical Outcome
Diffusion-Weighted MR Imaging Findings of Acute Necrotizing Encephalopathy
*Acute Necrotizing Encephalopathy Associated With Parainfluenza Virus in a Caucasian Child
*Acute Necrotizing Encephalitis -A Diagnostic Problem in Temporal Lobe Disease: Report of Three Cases
*The Brain Made Simple – A simple & straightforward Guide
*Acute Necrotising encephalitis of childhood
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